Oncogenesis and Molecular Biology of Pituitary Tumors (Frontiers of Hormone Research)

This comprehensive volume focuses on mechanisms leading to pituitary tumor formation and progression. The individual chapters provide timely updates on developments in the rapidly expanding field of pituitary tumor pathogenesis. Researchers from leading centers describe the fundamental functional anatomy of the pituitary, the structure and function of the hypothalamic hormone receptors as they relate to human pituitary adenomas, as well as disordered transcription factors, growth factors and signaling proteins in pituitary tumorigenesis. They also present transgenic models of pituitary tumor formation and report on chromosomal deletions observed in both hereditary and sporadic adenomas. The book is an essential and timely resource for basic and clinical endocrinologists, neurosurgeons and neuro-oncologists as it provides a state-of-the-art summary of our current understanding of the pathogenesis of these common tumors.