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Chirality in Drug Research (Methods & Principles in Medicinal Chemistry)
ISBN-13:
9783527310760
ISBN-10:
3527310762
Edition:
1
Author:
Wolfgang Lindner, Eric Francotte
Publication date:
2006
Publisher:
Wiley-VCH
Format:
Hardcover
370 pages
FREE US shipping
Book details
ISBN-13:
9783527310760
ISBN-10:
3527310762
Edition:
1
Author:
Wolfgang Lindner, Eric Francotte
Publication date:
2006
Publisher:
Wiley-VCH
Format:
Hardcover
370 pages
Summary
Chirality in Drug Research (Methods & Principles in Medicinal Chemistry) (ISBN-13: 9783527310760 and ISBN-10: 3527310762), written by authors
Wolfgang Lindner, Eric Francotte, was published by Wiley-VCH in 2006.
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Description
Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
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