Liposomes: Methods and Protocols, Volume 2: Biological Membrane Models (Methods in Molecular Biology, 606)
ISBN-13:
9781607614463
ISBN-10:
1607614464
Edition:
2010
Author:
Volkmar Weissig
Publication date:
2009
Publisher:
Humana
Format:
Hardcover
564 pages
Category:
Biochemistry
,
Chemistry
,
Molecular Biology
,
Evolution
,
Pharmacology
,
Biological Sciences
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Book details
ISBN-13:
9781607614463
ISBN-10:
1607614464
Edition:
2010
Author:
Volkmar Weissig
Publication date:
2009
Publisher:
Humana
Format:
Hardcover
564 pages
Category:
Biochemistry
,
Chemistry
,
Molecular Biology
,
Evolution
,
Pharmacology
,
Biological Sciences
Summary
Liposomes: Methods and Protocols, Volume 2: Biological Membrane Models (Methods in Molecular Biology, 606) (ISBN-13: 9781607614463 and ISBN-10: 1607614464), written by authors
Volkmar Weissig, was published by Humana in 2009.
With an overall rating of 3.6 stars, it's a notable title among other
Biochemistry
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Description
Efforts to describe and model the molecular structure of biological membranes go back to the beginning of the last century. In 1917, Langmuir described membranes as a layer of lipids one molecule thick [1]. Eight years later, Gorter and Grendel concluded from their studies that “the phospholipid molecules that formed the cell membrane were arranged in two layers to form a lipid bilayer” [2]. Danielli and Robertson proposed, in 1935, a model in which the bilayer of lipids is sequestered between two monolayers of unfolded proteins [3], and the currently still accepted fuid mosaic model was proposed by Singer and Nicolson in 1972 [4]. Among those landmarks of biomembrane history, a serendipitous observation made by Alex Bangham during the early 1960s deserves undoubtedly a special place. His fnding that exposure of dry phospholipids to an excess of water gives rise to lamellar structures [5] has opened versatile experimental access to studying the biophysics and biochemistry of biological phospholipid membranes. Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists. In vol. II of this book, the reader will fnd detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies.
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