Cell Culture Bioprocess Engineering

This reference guide is designed for industrial practitioners of mammalian cell cultivation for the production of biologics. It is the culmination of two decades of accumulated expertise, practical know-how and best practices in cell culture technology. Topics covered include: fundamentals of cell-biology and physiology, process engineering principles in stoichiometry, reactor kinetics and scale up. This unique reference manual combines the most current academic research with the very practical setting of today's industrial laboratories. The books aims to benefit Scientists and engineers in the field, working to maximize and troubleshoot production under real-life constraints. Table of Contents: 1. Overview of Cell Culture Technology 2. Cell Biology for Bioprocessing 3. Cell Physiology for Process Engineering 4. Medium Design for Cell Culture Processing 5. Cell Line Development 6. Stoichiometry and Kinetics of Cell Cultivation 7. Cell Culture Data Analysis 8. Metabolic Flux Analysis in Cell Culture Systems 9. Cell Culture Bioreactors 10. Oxygen Transfer in Cell Culture Bioreactors 11. Fedbatch Culture and Dynamic Nutrient Feeding 12. Cell Retention and Perfusion 13. Scaling Up and Scaling Down for Cell Culture Bioreactors 14. Cell Culture Genomics 15. Index