Drug-Drug Interactions (Drugs and the Pharmaceutical Sciences, 179)

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.

Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:

• key interplay between transporters and enzymes in drug metabolism and drug interactions
• the integral role of pharmacogenetics in metabolism-based drug-drug interactions
• in vivo – in vitro correlations (reversible, mechanism-based inhibition, induction)
• in silico approaches enabling structure-activity and structure-function studies
• high-throughput screening and GLP methods for evaluating drug interactions in vitro
• the use of transgenic animal models to evaluate drug interactions

Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.