Advances in Medicinal Chemistry (Volume 4)
ISBN-13:
9780762300648
ISBN-10:
0762300647
Edition:
1
Author:
B.E. Maryanoff, A.B. Reitz
Publication date:
1999
Publisher:
Elsevier Science
Format:
Hardcover
321 pages
Category:
Molecular Biology
,
Evolution
,
Organic
,
Chemistry
,
General & Reference
,
Chemistry
,
Pharmacology
,
Pharmacy
,
Biology
,
Biological Sciences
FREE US shipping
Book details
ISBN-13:
9780762300648
ISBN-10:
0762300647
Edition:
1
Author:
B.E. Maryanoff, A.B. Reitz
Publication date:
1999
Publisher:
Elsevier Science
Format:
Hardcover
321 pages
Category:
Molecular Biology
,
Evolution
,
Organic
,
Chemistry
,
General & Reference
,
Chemistry
,
Pharmacology
,
Pharmacy
,
Biology
,
Biological Sciences
Summary
Advances in Medicinal Chemistry (Volume 4) (ISBN-13: 9780762300648 and ISBN-10: 0762300647), written by authors
B.E. Maryanoff, A.B. Reitz, was published by Elsevier Science in 1999.
With an overall rating of 3.9 stars, it's a notable title among other
Molecular Biology
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Description
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
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