The Molecular Basis of Cell Cycle and Growth Control

Recent advances in our understanding of the biochemical and molecular mechanisms of cell growth and control have led to sensational breakthroughs in the diagnosis and treatment of proliferative and neoplastic diseases. As a consequence, cell growth and regulation has become a subject of vital interest to basic researchers and clinicians alike. Never has the need for authoritative reviews such as this been greater.

Comprising contributions by an international team of scientists at the forefront of one of today's liveliest areas of biomedical research, this book reports on the state-of-the-science in cell growth and regulation from the conceptual, experimental, and clinical perspective. Written at a level that will appeal to professionals as well as graduate and medical students, it explores a wide range of related topics, with an emphasis on the identification of checkpoints and restriction points and the mechanisms of proliferation competency and cell cycle progression, including:
* DNA replication and S phase
* Mitosis and meiosis
* Gene expression and gene regulatory mechanisms
* Signal transduction and integration of regulatory information
* Differentiation, development, and programmed cell death
* Cellular senescence and immortalization