Drinking Water and Health, Volume 9: Selected Issues in Risk Assessment (Drinking Water and Health, Vol 9)

The National Research Council closes the landmark series Drinking Water and Health with Volume 9, published in two parts: Part I: DNA Adducts provides an overview of DNA adducts and their effects on human health, explores the techniques currently in use for detecting them, offers an outlook on future toxicity testing, and lists specific recommendations for action. Part II: Mixtures explores the issues surrounding multiple-chemical exposure from drinking water and reviews options for grouping compounds so their toxicity in mixtures can be reliably assessed. The book describes alternative approaches and considers the option of developing a modified "hazard index" for chemical compounds. Table of ContentsFront MatterPart I: DNA AdductsExecutive Summary1 Biologic Significance of DNA Adducts and Protein Adducts2 DNA-Adduct Technology3 Conclusions and RecommendationsAppendix A: Drinking Water Contaminant Candidates for Development of Baseline Data on Formation of DNA AdductsGlossaryBiographical SketchesPart II: MixturesExecutive Summary1 Introduction2 Pharmacokinetics and the Risk Assessment of Drinking Water Contaminants3 Risk Assessment of Mixtures of Systemic Toxicants in Drinking Water4 Assessment of Exposure to Organophosphorus Conpounds, Carbamates, and Volatile Organic Chemicals5 Acetylcholinesterase Inhibitors: Case Study of Mixtures of Contaminates with Similar Biologic Effects6 Volatile Organic Compounds (VOCs): Risk Assessment of Mixtures of Potentially Carcinogenic Chemicals7 Conclusions and Recommendations for ResearchAppendix A: An Approach for Risk Assessment of Volatile Organic Chemicals in Drinking Water That Uses Experimental Inhalation Data and a Physiologically Based Pharmacokinetic ModelAppendix B: A Model Illustrating SynergismAppendix C: Models of Response: Dose Additivity and Response AdditivityBiographical SketchesPart III: Cumulative IndexIndex