9783540255970-3540255974-Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology (296))

Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology (296))

ISBN-13: 9783540255970
ISBN-10: 3540255974
Edition: 2005
Publication date: 2005
Publisher: Springer
Format: Hardcover 175 pages
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Book details

ISBN-13: 9783540255970
ISBN-10: 3540255974
Edition: 2005
Publication date: 2005
Publisher: Springer
Format: Hardcover 175 pages

Summary

Acknowledged author wrote Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology (296)) comprising 175 pages back in 2005. Textbook and eTextbook are published under ISBN 3540255974 and 9783540255970. Since then Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology (296)) textbook was available to sell back to BooksRun online for the top buyback price or rent at the marketplace.

Description

The purpose of this review is to examine the potential role of molecular mimicry in the pathogenesis of human T-lymphotropic virus type 1 ((HTLV- 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)). Comp- hensive reviews on the pathogenic mechanisms of HTLV-1-associated human diseases are available throughout the medical literature (Bangham 2000,, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002). Approximately 25 years ago the ?rst human retrovirus, HTLV-1, was isolated (Poeisz et al. 1980). Subsequently, infection with HTLV-1 was shown to cause adult T-cell leukemia (ATL) and HAM/TSP (Gessain et al. 1985; McFarlin and Blattner 1991; Osame et al. 1986; Poeisz et al. 1980; Yoshida et al. 1987). HTLV-1 may infect up to 30% of people in endemic areas and 10–20 million people worldwide (Barmak et al. 2003; Edlich et al. 2000). However, only 1%–5% develop either ATL or HAM/TSP, the remainder being clinically asymptomatic carriers of HTLV-1 (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002). Why infection with HTLV-1 causes ATL or HAM/TSP in some people while the vast majority of individuals are asymptomatic is largely - known. Some possible factors that may differentiate the asymptomatic from the diseased state include viral strain, human histocompatibility leukocyte antigen (HLA), viral load, and the immune response (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Nagai et al. 1998; Niewiesk et al. 1994; Osame 2002).

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