9783540225652-354022565X-Cannabinoids (Handbook of Experimental Pharmacology (168))

Cannabinoids (Handbook of Experimental Pharmacology (168))

ISBN-13: 9783540225652
ISBN-10: 354022565X
Edition: 2005
Publication date: 2005
Publisher: Springer
Format: Hardcover 784 pages
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Book details

ISBN-13: 9783540225652
ISBN-10: 354022565X
Edition: 2005
Publication date: 2005
Publisher: Springer
Format: Hardcover 784 pages

Summary

Acknowledged author wrote Cannabinoids (Handbook of Experimental Pharmacology (168)) comprising 784 pages back in 2005. Textbook and eTextbook are published under ISBN 354022565X and 9783540225652. Since then Cannabinoids (Handbook of Experimental Pharmacology (168)) textbook was available to sell back to BooksRun online for the top buyback price or rent at the marketplace.

Description

Less than 20 years ago the ?eld of cannabis and the cannabinoids was still c- sidered a minor, somewhat quaint, area of research. A few groups were active in the ?eld, but it was already being viewed as stagnating. The chemistry of cannabis 9 9 was well known, ? -tetrahydrocannabinol (? -THC), identi?ed in 1964, being the only major psychoactive constituent and cannabidiol, which is not psychoactive, possibly contributing to some of the effects. These cannabinoids and several s- thetic analogs had been thoroughly investigated for their pharmacological effects. Their mode of action was considered to be non-speci?c. The reasons for this - sumption were both technical and conceptual. On the technical side, it had been shown that THC was active in both enantiomeric forms (though with a different level of potency) and this observation was incompatible with action on biological substrates―a receptor, an enzyme, an ion channel―which react with a single stereoisomer only. The conceptual problem related to THC activity. This had been pointed out by several highly regarded research groups that had shown that many of the effects seen with cannabinoids were related to those of biologically active lipophiles, and that many of the effects of THC, particularly chronic ones, were comparable to those seen with anaesthetics and solvents.

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