9783527330157-3527330151-Bioisosteres in Medicinal Chemistry

Bioisosteres in Medicinal Chemistry

ISBN-13: 9783527330157
ISBN-10: 3527330151
Edition: 1
Publication date: 2012
Publisher: Wiley-VCH
Format: Hardcover 256 pages
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Book details

ISBN-13: 9783527330157
ISBN-10: 3527330151
Edition: 1
Publication date: 2012
Publisher: Wiley-VCH
Format: Hardcover 256 pages

Summary

Acknowledged author wrote Bioisosteres in Medicinal Chemistry comprising 256 pages back in 2012. Textbook and eTextbook are published under ISBN 3527330151 and 9783527330157. Since then Bioisosteres in Medicinal Chemistry textbook was available to sell back to BooksRun online for the top buyback price or rent at the marketplace.

Description

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.

With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

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