9783527330157-3527330151-Bioisosteres in Medicinal Chemistry

Bioisosteres in Medicinal Chemistry

ISBN-13: 9783527330157
ISBN-10: 3527330151
Edition: 1
Author: Nathan Brown
Publication date: 2012
Publisher: Wiley-VCH
Format: Hardcover 256 pages
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Book details

ISBN-13: 9783527330157
ISBN-10: 3527330151
Edition: 1
Author: Nathan Brown
Publication date: 2012
Publisher: Wiley-VCH
Format: Hardcover 256 pages

Summary

Bioisosteres in Medicinal Chemistry (ISBN-13: 9783527330157 and ISBN-10: 3527330151), written by authors Nathan Brown, was published by Wiley-VCH in 2012. With an overall rating of 3.5 stars, it's a notable title among other Chemistry (Pharmacology) books. You can easily purchase or rent Bioisosteres in Medicinal Chemistry (Hardcover) from BooksRun, along with many other new and used Chemistry books and textbooks. And, if you're looking to sell your copy, our current buyback offer is $0.39.

Description

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.

With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

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